Contemporary View about Pathogenesis of Inflammatory Bowel Diseases. Role of Matrix Metalloproteinases and Theirs Inhibitors

The incidence of ulcerative colitis, Crohn’s disease is increased and as a result causes the constant increasing number of studies on the pathogenesis of these diseases. This article gives an overview of researches concerning the role of matrix metalloproteinases and their inhibitors in the pathogenesis of inflammatory bowel disease in the last few decades. The study of features of the expression of molecular – biological markers of the extracellular matrix, such as TIMP-1 and MMP-9 in patients with ulcerative colitis is caused by the necessity of determination of the role of these indicators in assessing the severity of disease prognosis. Study of this issue is important, since this category of patients is necessary to achieve not only the clinical, but endoscopic and histological remission too and as a consequence the development of reliable criteria for assessing remission.